Research focuses on understanding and developing advanced techniques in mass spectrometry and applying them to the detection, identification, and accurate quantitation of trace levels of organic compounds and biomolecules in human blood and tissues and other matrices. Available instrumentation includes (1) four triple quadrupole mass spectrometers with electrospray and nanospray ionization, (2) four liquid chromatography/mass spectrometry systems with electrospray and atmospheric pressure chemical ionization, (3) two MALDI-time-of-flight (TOF) mass spectrometers (MS) with reflectron capabilities, (4) a hybrid quadrupole time-of-flight (Q-TOF) mass spectrometer, and (5) a linear ion trap mass spectrometer with ETD capabilities.

We encourage research that is related to electrospray and other techniques suitable for coupling liquid chromatography or capillary electrophoresis to mass spectrometry, particularly if the work may lead to developing techniques for the quantitation of polar and nonvolatile analytes in complex matrices. We are also interested in development of the quantitative potential of LC/MS/MS and MALDI-TOF MS for the determination of proteins and peptides of clinical importance using proteomics approaches.

 

key words

Clinical diagnostics; Electrophoresis; Liquid chromatography; Mass spectra; Proteins;

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral applicants