Current research projects explore the following subjects: (1) the mechanisms by which toxic compounds acutely affect central putative neurotransmitter systems with regard to neurotransmitter levels and related enzymatic activity, the interaction between enzyme inhibition and neurotransmitter levels in various brain areas, and the effects of potential antidotal compounds on these parameters; and (2) the mechanisms of action of anticonvulsant and/or neuroprotectant drugs on seizure activity and neuropathology induced subsequent to chemical toxicity. The chemical toxicants of interest are organophosphorus anticholinesterases nerve agents.

These research projects involve electrophysiological, neuropharmacological, neurochemical, and neurotoxicological studies on central neurotransmission using EEG analysis procedures, in vivo microdialysis, high-performance liquid chromatography with electrochemical detection, colorimetric and spectrophotometric techniques, and functional observation battery behavioral assessment in rodents.

 

References

Thomas TP, Shih TM: Toxicology Mechanisms and Methods 24: 385-395, 2014

Shih TM, et al: Advanced Studies in Biology 4: 451-478, 2012

 

key words

Acetylcholinesterase inhibition and reactivation; Anticholinergic compounds; Anticonvulsant drugs; Neuroprotectant drugs; Antidotes for nerve agents; Brain; Convulsions and seizures; Electrophysiology; Neuropharmacology; Neurotoxicology; Neurotransmitters; Oxime reactivators; In vivo microdialysis;

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral applicants