Walter Reed Army Institute of Research, Infectious Diseases-Viral Diseases Branch
name |
email |
phone |
|
Matthew Conte |
matthew.a.conte.ctr@health.mil |
301.319.7205 |
Advances in next generation sequencing and bioinformatics have resulted in major developments in the field of infectious disease research and genomic surveillance. With the COVID-19 pandemic, for instance, genomic surveillance has increasingly been used by public health for contact tracing, for determination of virus origins and points of introductions, identification of potential drivers of the evolutionary dynamics, and for surveillance of virus evolution and important mutations that may result in change of virus phenotype. This position will involve research and development of methods for genomic surveillance and virus evolution, including respiratory and FVBI human pathogens of DoD importance. In addition to population-level studies, intra-host pathogen evolution and diversity will be studied, for analyses of transmission, resistance, host adaptation, disease severity and general within-host pathogen evolution, and its correlates to immune responses, infection, therapy response and pathogen spread. This opportunity will involve computational analyses of virus and patient data, as well as development of new methods and tools for further advancement of the field. Familiarity with next generation sequencing technology, advanced bioinformatics tools (including proficiency in R and python), and experience with phylogenetic and phylodynamic modelling is significantly desired.
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