Opportunity at National Institute of Standards and Technology (NIST)
Oligonucleotide Analysis by Mass Spectrometry
Material Measurement Laboratory, Biomolecular Measurement Division
Please note: This Agency only participates in the February and August reviews.
|Mark Scott Lowenthal
Robust analytical characterization of oligonucleotides is essential to the production of safe and consistent RNA-based products, and is a necessary part of a biomanufacturing design. This opportunity focuses on developing advanced techniques in mass spectrometry for detecting, identifying, and quantifying oligonucleotides and impurities in various forms, with a focus on healthcare, therapeutics, and vaccines. Available instrumentation includes high resolution mass spectrometry (QToF, QExactive, Orbitrap) and quantitative mass spectrometry (QQQ-MS) with liquid chromatography. We encourage applicants who want to join a growing field and make an impact.
oligonucleotides; RNA; mass spectrometry; LC-MS/MS; therapeutics; vaccines; CRISPR-Cas; mRNA
Open to U.S. citizens
Open to Postdoctoral applicants