NRC Research Associate Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies

  sign inOpen Printer View

Opportunity at U.S. Army CCDC Soldier Center (CCDC SC)

Antimicrobial Peptide-based 3D Printed Microfluidic Multiplexed Biosensors for Biological Threats


U.S. Army CCDC Soldier Center, Biotechnology

RO# Location
39.01.01.B8081 Natick, MA 017605020


name email phone
Joshua Robert Uzarski 508.206.3942


The current state-of-the-art and fastest detection of deleterious bio-agents relies heavily on specific target molecules (antibodies) and genetic sequencing amplification (PCR).  The drawbacks to these techniques include lack of environmental stability, production cost, and insufficiently fast response time, and any of these precludes their use in dynamic field environments.  Furthermore, engineering attempts to obviate some of these drawbacks encounter production limitations in terms of device fabrication standards.  We are attempting to simultaneous overcome these limitations to realize a true fieldable bio-agent sensor by utilizing the following aspects:  1)  Antimicrobial peptide (AMP) multiplexed arrays for multi-agent detection; 2) novel data science drive algorithms for fast and accurate detection; 3) self-supported curvilinear 3D printed microfluidic devices with concurrent sensing ligand depositions.  We have previously demonstrated the capability of small AMP sensor arrays to discriminate bacterial lipopolysaccharides as well as the performance of 3D printed microfluidic sensor arrays.  Herein the objective is to discover new sets of AMP arrays for specific bio-agent targets including viruses, Gram positive bacteria, and biotoxins.  The candidate will be tasked with developing the ideal AMP sequences, contributing to sensor platform and device design and testing device response to select targets in different media and environments to inform concurrent collaborative data science work to improve sensor target recognition accuracy and response times.


Reichart, T.; Uzarski, J. R.; Mello, C., Differential Presentation of a Single Antimicrobial Peptide is Sufficient to Identify LPS from Distinct Bacterial Samples. The Analyst 2019

Han, X.; Uzarski, J. R.; Mello, C. M.; Chen, Z., Different interfacial behaviors of N-and C-terminus cysteine-modified cecropin P1 chemically immobilized onto polymer surface. Langmuir 2013, 29 (37), 11705-11712

Uzarski, J. R.; Mello, C. M., Detection and classification of related lipopolysaccharides via a small array of immobilized antimicrobial peptides. Anal Chem 2012, 84 (17), 7359-66

Biosensors; Antimicrobial peptides; 3D printed microvfluidics; functional materials; Chem/bio protection;


Citizenship:  Open to U.S. citizens and permanent residents
Level:  Open to Postdoctoral and Senior applicants


Base Stipend Travel Allotment Supplementation
$63,800.00 $2,000.00

$5,000 Supplement for Doctorates in Engineering & Computer Science

Experience Supplement:
Postdoctoral and Senior Associates will receive an appropriately higher stipend based on the number of years of experience past their PhD.

Copyright © 2022. National Academy of Sciences. All rights reserved.Terms of Use and Privacy Policy