Our laboratory uses biochemical and molecular biology approaches to study intracellular signaling. We have a special interest in understanding processes mediated by inducible heat shock protein 70 (HSP-70i) and inducible nitric oxide synthase (iNOS) after exposure to skin-wound trauma and ionizing radiation. Our long-term goal is to design ways to block the iNOS/NF-IL6 pathway and the p53/p21/bax pathway in order to prevent tissue injury. We are also investigating the relationship between stress gene responses and exposure to hypoxia or radiation to determine whether the responses can be used as exposure indicators to help guide treatment approaches. The involvement of apoptosis, ATP metabolism, and microRNA regulation in response to radiation and hypoxia are also being investigated.

References

Kiang JG, et al: Radiation Research 173: 319, 2010

Kiang JG, et al: Adaptive Medicine 2: 1, 2010

Kiang JG, et al: PLoS ONE 10: e0139271, 2015

Swift JM, et al: Radiation Research 183: 578-583, 2015

Kiang JG:Adaptive Medicine 9: 28-33, 2017