Opportunity at U.S. Army CCDC Chemical Biological Center (CCDC CBC)
In Vitro Models of Organ Toxicity
U.S. Army CCDC - Chemical Biological Center, Chemistry & Chemical Technology
||Aberdeen Proving Ground, MD 210105423
|Glover, Kyle Philip
Emerging chemical threats of interest to the chemical biological defense (CBD) program have the potential to cause systemic and/or localized target organ toxicities in response to acute exposure. While traditional in vivo models have been useful to characterize these threats in the past, new methodologies that utilize human tissue and replicate mechanistic functionality of organ systems have the potential to substantially reduce the animal testing burden of the CBD program, reduce costs, streamline testing needs and deliver more rapid characterizations of new threats with human relevant detail. This research opportunity will develop and/or optimize existing organoid systems to characterize human toxicity. Of primary concern is respiratory toxicity, where replication of lung physiology can be difficult in vitro and exposure to aerosolized compounds can be cumbersome. However, development and/or optimization of other organoid models that replicate cardiac, hepatic, vascular and central nervous system acute toxicity will also be considered.
Toxicology; Physiology; In Vitro; Lung; Inhalation
Open to U.S. citizens
Open to Postdoctoral and Senior applicants
$5,000 Supplement for Doctorates in Engineering & Computer Science
$4,050 Supplement for each year of experience in the DTRA CBD-funded NRC tenure at CCDC.
Postdoctoral and Senior Associates will receive an appropriately higher stipend based on the number of years of experience past their PhD.