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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

To Study Changes in the Coagulation and Immune Systems after Trauma and Blood Loss

Location

U.S. Army Institute of Surgical Research, US Army Institute of Surgical Research

RO# Location
97.40.00.B7896 Fort Sam Houston, TX 782346315

Advisers

Name E-mail Phone
Darlington, Daniel Norman daniel.n.darlington.civ@mail.mil 210 539 3769

Description

Polytrauma and hemorrhagic shock caused by blunt/penetration trauma or blast can lead to multiple clinical challenges that include coagulopathy, immune dysfunction, multiple organ failure, and acute lung injury. Our laboratory studies the physiological changes that occur after trauma and blood loss in order to develop better resuscitation fluids and strategies to prevent or attenuate the negative changes that occur. Currently we are studying the change in the coagulation and immune system, focusing on platelet and leukocyte function after trauma. Work could involve both large and small animal models of trauma/hemorrhage, as well as components of human blood. We perform many laboratory assays and measurements using ELISA, HPLC, mass spectroscopy, cells sorting and counting, physical parameters of clot formation, and the cell biology of platelets and leukocytes.

 

References

Darlington DN, et al: Shock 39(5): 440, 2013

Brohi MJ, et a1: Current Opinion in Critical Care 13(6): 680, 2007

 

Keywords:
Coagulation; Inflammation; Hemorrhage; Trauma; Biochemistry; Hemostasis; Resuscitation; Organ failure; Immune function;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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