Polytrauma and hemorrhagic shock caused by blunt/penetration trauma or blast can lead to multiple clinical challenges that include coagulopathy, immune dysfunction, multiple organ failure, and acute lung injury. Our laboratory studies the physiological changes that occur after trauma and blood loss in order to develop better resuscitation fluids and strategies to prevent or attenuate the negative changes that occur. Currently we are studying the change in the coagulation and immune system, focusing on platelet and leukocyte function after trauma. Work could involve both large and small animal models of trauma/hemorrhage, as well as components of human blood. We perform many laboratory assays and measurements using ELISA, HPLC, mass spectroscopy, cells sorting and counting, physical parameters of clot formation, and the cell biology of platelets and leukocytes.

 

References

Darlington DN, et al: Shock 39(5): 440, 2013

Brohi MJ, et a1: Current Opinion in Critical Care 13(6): 680, 2007

 

key words

Coagulation; Inflammation; Hemorrhage; Trauma; Biochemistry; Hemostasis; Resuscitation; Organ failure; Immune function;

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens

Level:  Open to Postdoctoral and Senior applicants