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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Microvascular Function in Hemorrhage and Trauma

Location

U.S. Army Institute of Surgical Research, US Army Institute of Surgical Research

RO# Location
97.40.00.B7782 Fort Sam Houston, TX 782346315

Advisers

Name E-mail Phone
Torres Filho, Ivo P ivo.p.torresfilho.civ@mail.mil 210.460.9744

Description

This program employs standard and confocal intravital video microscopy, as well as other novel techniques to evaluate the efficacy of resuscitation fluids and other interventions in the treatment of trauma and hypovolemia due to hemorrhage. The program also evaluates platelet function under blood flow conditions in vivo and includes (1) studies of mechanisms associated with the microhemodynamic, biochemical, hormonal, and other immunological alterations associated with trauma and/or hemorrhage; (2) the influence of factors such as central nervous system trauma, glycocalyx degradation, coagulopathy, dehydration, and oxygen radicals on the response to trauma, hemorrhage, and resuscitation efforts; and (3) the role of cytokines and growth factors, and proteolytic enzymes in mechanisms associated with trauma. The studies also help identify better platelet storage strategies. In vivo studies employ microsurgical, biochemical, and physiological techniques, while off-line analysis utilizes complex digital image analysis techniques.

 

Keywords:
Microcalculation; Intravital microscopy; Hemorrhage; Glycocalyx; Oxidative injury; Traumatic injury; Permeability; Coagulopathy; Platelet-endothelial cell interaction;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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