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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Molecular and Cellular Toxicological Mechanisms of Chemical Agents

Location

U.S. Army Medical Research Institute of Chemical Defense, Comparative Medicine Division

RO# Location
97.25.10.B6880 Aberdeen Proving Ground, MD 210105425

Advisers

Name E-mail Phone
Ruff, Albert Leonard albert.l.ruff2.civ@mail.mil 410.436.8456

Description

Our laboratory focuses on investigating the molecular and cellular responses that occur in toxicant exposure to identify and validate therapeutic targets for treating toxicant-induced injuries. Toxicant exposure is studied in both in vitro and in vivo models of injury with particular emphasis on ocular exposure. We utilize a wide variety of molecular and cellular techniques including high content analysis, proteomics, genomics, RNAi, primary cell culture, multiplex ELISA, and others to identify signaling molecules and pathways activated or modified in toxicant exposure. We are particularly interested in pathways involved in inflammation, cellular trafficking, apoptosis, cell structure, and neurodegeneration. Elucidating the molecular events following toxicant exposure is likely to identify the mechanisms of injury and the major regulators of the cellular response to the toxicant. Knowledge of these regulators and their roles in the mechanisms of injury is necessary for the rational development of effective therapeutics to treat toxicant exposure.

 

Keywords:
Signal transduction; Inflammation; Genomics; Cell biology; Toxicology; Proteomics; Molecular biology; Therapeutics;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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