Our laboratory focuses on investigating the molecular and cellular responses that occur in toxicant exposure to identify and validate therapeutic targets for treating toxicant-induced injuries. Toxicant exposure is studied in both in vitro and in vivo models of injury with particular emphasis on ocular exposure. We utilize a wide variety of molecular and cellular techniques including high content analysis, proteomics, genomics, RNAi, primary cell culture, multiplex ELISA, and others to identify signaling molecules and pathways activated or modified in toxicant exposure. We are particularly interested in pathways involved in inflammation, cellular trafficking, apoptosis, cell structure, and neurodegeneration. Elucidating the molecular events following toxicant exposure is likely to identify the mechanisms of injury and the major regulators of the cellular response to the toxicant. Knowledge of these regulators and their roles in the mechanisms of injury is necessary for the rational development of effective therapeutics to treat toxicant exposure.

 

Keywords:

Signal transduction; Inflammation; Genomics; Cell biology; Toxicology; Proteomics; Molecular biology; Therapeutics;

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral and Senior applicants