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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Neurobehavioral Effects on Organophosphate Exposure

Location

U.S. Army Medical Research Institute of Chemical Defense, Comparative Medicine Division

RO# Location
97.25.10.B3578 Aberdeen Proving Ground, MD 210105425

Advisers

Name E-mail Phone
McDonough, John Henry john.h.mcdonough2.civ@mail.mil 410.436.1942

Description

Current research explores the following subject: (1) the mechanisms by which organophosphate agents affect the central nervous system to produce changes in brain function and how these changes in brain function are expressed behaviorally; (2) the mechanisms by which seizures develop following exposure to organophosphates, the functional and pathological consequences of these seizures, and how different classes of drugs can block or terminate this seizure activity; and (3) the short- and long-term neurobehavioral consequences of exposure to organophosphate agents. These projects involve neuropharmacological studies involving electrophysiological (quantitative EEG analysis), behavioral, and neuropathological analysis of drugs in whole animal preparations (rat, guinea pig, nonhuman primate).

 

Reference

Shih TM, Rowland TC, McDonough JH: Journal of Pharmacology and Experimental Therapeutics 320: 154, 2007

 

Keywords:
Behavioral toxicology; Organophosphorus; Central nervous system; Brain; Seizures; Behavioral pharmacology; Neuropharmacology;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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