Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)
Development and Application of Network Science Methods for the Study of Biological Interaction Networks
Telemedicine & Advanced Technology Research Center
||Frederick, MD 2l7025012
The elucidation of biological networks of organisms has been dramatically enhanced by the recent developments of high-throughput experiments that identify protein-protein (and other) interactions at a large scale. Together with the generation of this large data, new research areas have evolved that aim to visualize, characterize, and mathematically model the discovered networks. We are developing and applying computational approaches in order to study interaction networks of pathogens (and related species) as well as their modes of action on host organisms. The goals of this research include (1) the determination of similarities and/or differences across family members, (2) the prediction of good targets for drug development, (3) the construction and mathematical modeling of sub-networks and pathways to gauge the effects of environmental perturbations, and (4) the development of new systems biology modeling algorithms. Prospective applicants should possess exceptional analytical skills and have a strong background in at least one of the following areas: bioinformatics, mathematics, process modeling, computer science, and network/pathway modeling.
Network science; Biological networks; Interactions; Computational biology;