U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases
||Fort Detrick, MD 217025011
We are interested in characterizing novel virulence factors of B. mallei and B. pseudomallei, understanding the regulation of virulence factor gene expression and gaining a better understanding of the basic biology of these pathogens. The use of alternative models of infection to study bacterial pathogenesis is also a focus of our laboratory. In addition, we are interested in testing novel glanders and melioidosis vaccine candidates in animal models of infection.
Burtnick, M.N., Brett, P.J. and DeShazer, D. 2014. Proteomic analysis of the Burkholderia pseudomallei type II secretome reveals hydrolytic enzymes, novel proteins and the deubiquitinase TssM. Infect. Immun. 82(8):3214-3226.
Chua, J., Fisher, N.A., DeShazer, D., Friedlander, A.M. 2017. The Madagascar Hissing Cockroach as an alternative non-mammalian animal model to investigate virulence, pathogenesis and drug efficacy. J. Vis. Exp. (129), e56491, doi:10.3791/56491.
Burtnick, M.N., Shaffer, T.L., Ross, B.N., Muruato, L.A., Sbrana, E., DeShazer, D., Torres, A.G. and Brett, P.J. 2018. Development of subunit vaccines that provide high level protection and sterilizing immunity against acute inhalational melioidosis. Infect. Immun. 86(1):e00724-17. doi: 10.1128/IAI.00724-17.
vaccines; molecular biology; genetics; Burkholderia mallei; Burkholderia pseudomallei; pathogenesis