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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

The Development of Recombinant Protein Antigen Vaccines against Botulism

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B8424 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Webb, Robert Paul robert.p.webb6.civ@mail.mil 301.619.6686

Description

The United States Army Medical Research of Infectious Diseases (USAMRIID) is accepting applications for a postdoctoral position in the Molecular and Translation Sciences Division. The applicant should have experience in the design and application of de novo protocols for the purification of recombinant proteins by HPLC column chromatography and should be experienced with basic and advanced methods of protein characterization. Experience in basic techniques of recombinant DNA technology and in the use and maintenance of small scale bioreactors (2-14 L) for the growth of transgenic strains of yeast would also be desirable. The applicant must be able to obtain a favorable Single Scope Background Investigation (SSBI) and maintain enrollment in the Biological Personnel Reliability Program (BPRP) for handling select agents.

 

References

Shearer JD, Manetzb TS, House RV: Preclinical safety assessment of recombinant botulinum vaccine A/B (rBV A/B). Vaccine 30: 1917-1926, 2012

Webb RP, Smith LA: What next for botulism vaccines? Expert Review in Vaccines 12(5): 481-92, 2013

Moreira GMSG, et al: Production of recombinant botulism antigens: A review of expression systems. Volume 28: 130-136, August, 2014

 

Keywords:
Botulism; Protein purification; Recombinant protein; Yeast expression; Vaccine; Bioreactor;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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