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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Mass Spectrometry Based Proteomic and Metabolomic Studies

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B8365 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Cazares, Lisa H lisa.h.cazares.ctr@mail.mil 301.619.8564

Description

The Mass Spectrometry group at the US Army Medical Research Institute of Infectious Disease is seeking an Associate to aid in the development and application of mass spectrometry workflows to investigate proteomic and metabolomic changes, which occur in body fluids and tissues during viral and bacterial infection. The candidate will also be responsible for maintaining and running of the 7T FTICR and Triple Quadrapole mass spectrometry platforms for various projects. The ideal candidate will be familiar with the use of MALDI-FTICR MS imaging for the detection of peptides, small molecule metabolites and lipids in tissue sections in various animal models of infectious disease. We have a highly integrated work environment and work on many team and collaborative projects across multiple capabilities and disciplines. The candidate should have expertise in proteomic and metabolomics sample preparation methods, various separation modalities, data acquisition, data processing, and data interpretation. Candidates with additional expertise in top-down proteomics, metabolite detection by LC-MS, and tandem mass spectrometry are particularly encouraged.

 

References

Cazares LH, et al: Heat Fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging. BMC Microbiology 15(1): 101, 2015

Shurtleff AC, et al: Pre-symptomatic diagnosis and treatment of filovirus diseases. Frontiers in Microbiology, section Infectious Diseases. Frontiers in Microbiology 6: 108, 2015

Cazares LH, et al: MALDI Tissue imaging: from Biomarker Discovery to Clinical Applications. Analytical and Bioanalytical Chemistry 401(1): 17-27, 2011 Epub 2011 May 4. Review

 

Keywords:
Proteomics; Metabolomics; Mass spectrometry; Tissue imaging; Infectious disease;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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