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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Viral Evolution of Emerging Pathogen Threats under Positive Selection Center for Genomic Sciences

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B8339 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Palacios, Gustavo F gustavo.f.palacios.ctr@mail.mil 301.619.8732

Description

A position is available for a postdoctoral Associate interested in working on programs to study the effects of medical countermeasures in viral genome populations of extremely dangerous pathogens. The overarching goal of this line of research will be to characterize the mechanisms of viral evolution in response to antiviral drugs, passive immunotherapy, or vaccination. The overall goal will be to (1) define mechanisms of viral resistance or escape “in vivo”, (2) utilize viral evolution to define mechanisms of action for novel therapeutics, and (3) support medical countermeasures developmental plans by providing quality viral genomics data to regulatory agencies. USAMRIID is the lead Department of Defense (DOD) laboratory for biodefense research. The Center for Genome Sciences (CGS) hosts a wide-variety of research programs, all of which are enhanced by access to excellent BSL-3/4 biocontainment facilities for work with highly infectious bacterial and viral pathogens, as well as direct access to all next-generation sequencing platforms. The CGS is highly integrated with other departments within the Institute (e.g., countermeasure development, diagnostics and vaccine programs), which creates an ideal environment for interdisciplinary collaboration. Integration of genomics with programs for proteomics, metabolomics, high throughput imaging is highly encouraged.

The Associate will lead a technical and bioinformatics group focused on this area of research but will also have the opportunity to become involved with the other areas at CGS. A PhD with training in virology, viral evolution, and/or computational biology is required.

 

References

Kugelman JR, et al: Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail. Cell reports 12: 2111-2120, 2015; published online EpubSep 29 (10.1016/j.celrep.2015.08.038)

Warren TK, et al: A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection. mBio 6, 2015; 10.1128/mBio.02344-14

 

Keywords:
Viral population genomics; Viral evolution; Genomics; Systems Bbology; Research scientist;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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