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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Burkholderia pseudomallei Animal Modeling for Future Testing of Novel Medical Countermeasures

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B8337 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Cote, Christopher Kevin christopher.k.cote.civ@mail.mil 301.619.4936

Description

This project involves developing animal models for Burkholderia mallei and Burkholderia pseudomallei, the etiological agents of the diseases glanders and melioidosis. There are currently no effective vaccines against either of these bacteria and antibiotic resistance continues to be a concern for the biodefense community. Our work predominantly deals with developing mouse models of infection, characterizing the pathogenesis of the bacteria, and documenting the host immune response to the ensuing infection.

 

Reference

Welkos SL, et al: Characterization of Burkholderia pseudomallei strains using a murine intraperitoneal infection model and in vitro macrophage assays. PLoS One 10(4): e0124667, 2015

 

Keywords:
Glanders; Burkholderia mallei; Animal model; Burkholderia pseudomallei; Melioidosis; Mice;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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