Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)
Omics-based system level approaches to investigate biological consequences of bacterial infection and therapeutics at the molecular level
U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases
||Fort Detrick, MD 217025011
|Panchal, Rekha G.
Unlike the traditional approach of examining the host or pathogen separately, a systems-level approach, which considering the pathogen and host together as a whole, is essential to elucidate the mechanisms which contribute to the initiation, progression, and persistence of bacterial infections. Furthermore understanding infection-induced metabolic, lipidomics and proteomic changes can reveal pathways required for pathogenesis, identify targets for the prevention of host colonization, and reveal the metabolic cross-talk that occurs at the host-pathogen interface. Our research includes characterizing the large array of altered biomolecules using mass-spectrometry based proteomic studies and profile metabolites in infected and drug treated tissues using FTICR-imaging mass spectrometry. The data generated is used in computational network constructions to predict key pheotype of pathogenesis and novel identify novel therapeutic targets.
Proteomics; Lipidomics; Metabolomics; Systems biology; Novel drug targets;
Open to U.S. citizens, permanent residents and non-U.S. citizens
Open to Postdoctoral and Senior applicants