U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases
||Fort Detrick, MD 217025011
|Panchal, Rekha G.
Interactions between pathogens and host immune cells are complex, dynamic, and play a critical role in disease pathogenesis. The outcome of such interactions is a reflection of the properties of the microbial agent and the ability of the host to respond to infection. This outcome may range from disease, persistent infection within the host, or even microbe elimination. Pathogenic organisms and/or their virulence factors often exploit the host immune machinery and subsequently modulate cell function, signaling, migration, and cytoskeleton rearrangement. An emerging theme in microbe-host interaction is that evolutionarily distant pathogens exploit a number of common cellular pathways. Understanding the common cellular targets and immune dysfunction elicited by various microbes may offer critical intervention to deregulate functional immunity by disseminating the impact of invading microbes and leading to novel therapeutic strategies.
Our research focuses on studying host-pathogen interactions using state-of-the-art approaches such as chemical genetics, high-content imaging, phosphoproteomics, and systems biology and identifying novel host targets exploited by the diverse pathogens.
Panchal RG, et al: Journal of Biomolecular Screening 15(7): 755, 2010
Panchal RG, et al: Cell, Host & Microbe 6: 162, 2009
Panchal RG, et al: Journal of Biological Chemistry 284(19): 12874, 2009
Cell signaling; High content imaging; Phosphoproteomics; Immune cells; Infectious diseases; Kinases and phosphatases; Host-pathogen interaction; Drug discovery; Therapeutics;