The National Academies Logo
Research Associateship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies - AMRMC

  Sign InPrintable View

Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Host Immune Cell Signaling in Response to Pathogenic Agents

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B7146 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Panchal, Rekha G. rekha.g.panchal.civ@mail.mil 301.619.4985

Description

Interactions between pathogens and host immune cells are complex, dynamic, and play a critical role in disease pathogenesis. The outcome of such interactions is a reflection of the properties of the microbial agent and the ability of the host to respond to infection. This outcome may range from disease, persistent infection within the host, or even microbe elimination. Pathogenic organisms and/or their virulence factors often exploit the host immune machinery and subsequently modulate cell function, signaling, migration, and cytoskeleton rearrangement. An emerging theme in microbe-host interaction is that evolutionarily distant pathogens exploit a number of common cellular pathways. Understanding the common cellular targets and immune dysfunction elicited by various microbes may offer critical intervention to deregulate functional immunity by disseminating the impact of invading microbes and leading to novel therapeutic strategies.

Our research focuses on studying host-pathogen interactions using state-of-the-art approaches such as chemical genetics, high-content imaging, phosphoproteomics, and systems biology and identifying novel host targets exploited by the diverse pathogens.

 

References

Panchal RG, et al: Journal of Biomolecular Screening 15(7): 755, 2010

Panchal RG, et al: Cell, Host & Microbe 6: 162, 2009

Panchal RG, et al: Journal of Biological Chemistry 284(19): 12874, 2009

 

Keywords:
Cell signaling; High content imaging; Phosphoproteomics; Immune cells; Infectious diseases; Kinases and phosphatases; Host-pathogen interaction; Drug discovery; Therapeutics;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
Copyright © 2014. National Academy of Sciences. All rights reserved. 500 Fifth St. N.W., Washington, D.C. 20001.
Terms of Use and Privacy Statement.