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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Molecular Diagnostics and Pathogenesis

Location

U.S. Army Medical Research Institute of Infectious Diseases, US Army Medical Research Insti Infec Diseases

RO# Location
97.20.00.B5422 Fort Detrick, MD 217025011

Advisers

Name E-mail Phone
Schoepp, Randal J. randal.j.schoepp.civ@mail.mil 301.619.4159

Description

Basic and applied research opportunities are available to study many aspects for the detection and identification of new and emerging pathogens and their applications to other fields of study. This program focuses on the use of modern molecular techniques for the development of rapid, sensitive, and specific assays to detect and identify viruses, bacteria, and toxins. Systems being developed involve many different platforms that detect nucleic acids, antigens, or antibodies. Studies can involve basic research or be more applied in nature. The Diagnostic Systems Division’s scope of research spans many different scientific disciplines, which offers an individual a wide variety of research opportunities. Developments in molecular diagnostics can be used as the basis for collaborations throughout the Institute to study molecular pathogenesis, host response to infection, gene expression, and antigenic and genetic variation. Current research efforts include the development of recombinant antigens and antibodies to improve or support current diagnostic assays. Prokaryotic, eukaryotic, and plant expression systems are being used in this work. The improved diagnostic assays are being evaluated in austere environments in regions of the world where the diseases are endemic or emerging.  Basic research needs to support these applied efforts include epitope identification and characterization of biological threat agents, development of cloning and expression systems for recombinant antibodies to include phage-display technology, cloning and sequencing, epitope mapping, gene shuffling, and high-frequency mutagenesis. The Institute provides high-level biocontainment facilities, expert personnel, state-of-the-art equipment, and up-to-date molecular tools to support scientific studies.

 

Keywords:
Molecular diagnostics; Molecular pathogenesis; Recombinant antibodies; Recombinant antigens; Austere environments;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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