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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Performance Assessment, Preclinical Drug Development, and Chemical Evaluation

Location

Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Behaviorial Biology Branch

RO# Location
97.15.52.B6954 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Capaldi, Vincent F vincent.f.capaldi.mil@mail.mil 301.319.9098
Lowery-Gionta, Emily Geyer emily.g.lowery-gionta.ctr@mail.mil 301-319-7653

Description

We develop, implement, and utilize animal models that rely on general and cognitive performance to address specific problems of military relevance. In rodents we use operant behavior, maze performance, passive avoidance, discrimination paradigms, spontaneous motor activity, and other indices of learned and unlearned behavior to model performance. In non-human primates, we use list-memory tasks and customized behavioral tasks to model performance. These models are used to develop and evaluate novel pharmacological treatments for adverse conditions of specific interest to the military. The models are also used to assess health effects and the operational impact of agents and environmental conditions likely to be encountered on the battlefield. Research focuses on characterizing experimental drugs and on a multidisciplinary approach to investigate pharmacological and biochemical correlates of cognition and general performance. Collaboration with Institute and other DOD laboratory, psychologists, pharmacologists, physiologists, and biochemists is integral. Current interest areas include preclinical development of pharmacological therapies to treat PTSD, behavioral assessment of novel antimalarial compounds, safety assessment of countermeasures against organophosphorus toxicity, and the evaluation of the operational impact of a variety of threat agents.

 

References

Genovese RF, et al: Neurotoxicology and Teratology 31: 110, 2009

Genovese RF, Newman DB: Archives of Toxicology 82: 379, 2008

 

Keywords:
Neurotoxicology; Behavioral pharmacology; Stress; Cognition; Memory; Neuropharmacology; Animal performance;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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