The National Academies Logo
Research Associateship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies - AMRMC

  Sign InPrintable View

Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Neuroprotection and Brain Injury

Location

Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Brain Trauma Neuroprotection and Neurorestoration

RO# Location
97.15.51.B6955 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Lu, Xi-chun M xi-chun.m.lu.civ@mail.mil 301.319.9972

Description

The primary mission of our research program is to evaluate and develop neuroprotective and neurorestorative therapies to mitigate traumatic brain injury (TBI), which has become a serious problem for military personnel at war. Using a unique militarily relevant experimental model of penetrating ballistic-like brain injury (PBBI), we test a broad spectrum of therapeutic approaches to improve functional, physiological, and histological deficits resulting from the injury. Our in vivo neuroprotective program can be categorized into three major research areas: (1) preclinical characterization of potential neuroprotective drugs developed by pharmaceutical companies; (2) brain specific hypothermia achieved through an extraluminal carotid artery cooling cuff method to control cerebral metabolic balance after injuries; and (3) transplantation therapy with human amnion-derived stem cells as neurorestorative treatment for TBI. The therapeutic effects of these approaches are measured by comprehensive assessments, which include behavioral/cognitive analysis of functional recovery evaluated by balance-beam, rotarod, and Morris water maze tests; histopathological and immunohistochemical analysis of the lesion and molecular responses; and electrophysiology (EEG) analysis of silent brain seizures and power spectrum shift. The utmost goal of our research is to bring a neuroprotective therapy to clinical trial to facilitate the clinical development of treatment of TBI.

 

Keywords:
Electrophysiology (EEG, seizure); Traumatic brain injury; Penetrating brain injury; Neuroprotection; Neuropharmacology; Selective brain hypothermia; Stem cell therapy; Behavioral assessment; Cognitive assessment;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
Copyright © 2014. National Academy of Sciences. All rights reserved. 500 Fifth St. N.W., Washington, D.C. 20001.
Terms of Use and Privacy Statement.