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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Optimizing Transfluthrin Treated Devices for Deterrence of Mosquitoes from Approaching and Entering Permethrin Treated Tents

Location

Walter Reed Army Institute of Research, US Army Medical Research Directorate-Kenya

RO# Location
97.15.46.B8534 Nairobi, KENYA

Advisers

Name E-mail Phone
Mancuso, James D james.mancuso@usamru-k.org +254795748269

Description

Pyrethroid treated tents, blankets, and chaddars confer protection against indoor biting disease vectors and are less effective where mosquitoes and other vectors also bite outdoors. Apart from topical repellents, airborne insecticides that prevent mosquitoes from locating and biting potential hosts may be appropriate for outdoor settings. Airborne insecticides can be dispersed within a given space creating a “chemical bubble” that confers protection to those found within and nearby. This study aims to evaluate strategies of combining airborne transfluthrin with permethrin treated tents in order to achieve integrated control of mosquitoes and sand flies by reducing biting pressure both inside and outside tents. We will use transfluthrin treated emanators that allow passive emanation of the insecticide into a given space. The benefit of combining the two strategies will be determined by the reduction of mosquito bites inside tents and specific distances outside tents. The proportion of bites will be determined by human landing catches of male volunteers seated in and outside tents. Experiments will be conducted in a semi-field system using laboratory reared disease free Anopheles gambiae sensu stricto and An. arabiensis mosquitoes and Phlebotomus duboscqi sand flies. This will be followed by a phase 2 full-field experimental to determine efficacy of the intervention against naturally occurring wild mosquitoes. This study will be conducted in a malaria endemic region in western Kenya.

 

References

Ogoma BS, et al: The mode of action of spatial and their impact on vectorial capacity of Anopheles gambiae sensu stricto. PLoS One 9(12): e110433, 2014

Maia MF, et al:  Do Topical Repellents Divert Mosquitoes within a Community?- Health Equity Implications of Topical Repellents as a Mosquito Bite Prevention Tool. PLoS One 8: e84875, 2013

Ogoma BS, et al: Spatial repellency of transfluthrin-treated hessian against laboratory-reared Anopheles arabiensis mosquitoes in a semi-field tunnel cage. Parasites & Vectors 5: 54, 2012

 

Keywords:
Anopheles gambiae; Malaria; Spatial repellants; Mosquitoes; Leishmaniasis; Sand flies;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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