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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Malaria—Immunology

Location

Walter Reed Army Institute of Research, Infectious Diseases-Military Malaria Research Program-Malaria Vaccine Branch

RO# Location
97.15.30.B3388 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Krzych, Urszula urszula.krzych1.civ@mail.mil 301.319.9558

Description

Research involves (1) analysis of cellular and humoral immune responses to malaria vaccine candidates and (2) elucidation of cellular mechanisms involved in mediating anti-malaria protective immunity in human and murine model systems induced by immunization with radiation-attenuated and genetically-attenuated Plasmodia sporozoites. Vaccines involving recombinant Plasmodium falciparum CSP, LSA-1, AMA-1, and MSP-1 are being developed in preclinical and clinical Phase I and Phase II trials. A major effort is devoted to studies of liver-stage immunity using a panel of newly discovered liver-stage antigens.

Anti-malarial vaccines developed and manufactured at WRAIR or with major pharmaceutical partners are delivered with human-use adjuvants or as live vectors. While we analyze and optimize the immune responses to the vaccines in murine and non-human primate systems, our major goal is to understand the immune response in human vaccine volunteers from clinical trials. Our primary goal is to elucidate protective mechanisms involving antibodies or T-cell subsets that mediate cellular effector functions. In addition, a major study involving microarray data sets of the entire human genome response to malaria vaccines is being undertaken in order to understand the whole body response to vaccines and control of infection.

 

Keywords:
Malaria; Antigens; Microarrays; Vaccines; T cells;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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