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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Immunology and Systems Biology of Dengue Virus Vaccination and Natural Infections

Location

Walter Reed Army Institute of Research, Infectious Diseases-Viral Diseases Branch

RO# Location
97.15.12.B8285 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Currier, Jeffrey R jeffrey.r.currier.civ@mail.mil 240.994.3911
Jarman, Richard George richard.g.jarman.mil@mail.mil 301.319.9223

Description

The Department of Immunology, Viral Diseases Branch (VDB) of the Walter Reed Army Institute of Research investigates immune responses to vaccination and natural infections of viral diseases. Current research focuses on immune monitoring through standardized T-Cell and B-Cell assays using ELISPOT, Luminex, multiparameter flow cytometry, and FACS technologies available in-house. Our objective is to identify potential correlates of protection and garner a deep understanding of dengue immunity and immune responses to candidate dengue vaccines. The Branch currently has several dengue vaccine candidates in clinical trials and will be utilizing dengue human infection models to evaluate vaccine candidates. The VDB is seeking applicants to advance immune investigations, in particular using single cell analysis and systems biology approaches.

 

References

Rothman et al: Analysis of cell-mediated immune responses in support of dengue vaccine development efforts. Vaccine 30: 7083-7090, 2015

Martinez et al: Safety and Immunogenicity of a Dengue Virus Serotype-1 Purified-Inactivated Vaccine: Results of a Phase 1 Clinical Trial. American Journal of Tropical Medicine and Hygiene 93: 454-460, 2015

Nakaya et al: Systems biology of vaccination for seasonal influenza in humans. Nature Immunology 12: 786-795, 2011

 

Keywords:
Dengue; Flow cytometry; Immunology; Systems biology; Viral diseases; Dengue; ICS; T-cells; Transcriptomics;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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