The Department of Immunology, Viral Diseases Branch (VDB) of the Walter Reed Army Institute of Research investigates immune responses to vaccination and natural infections of viral diseases. Current research focuses on immune monitoring through standardized T-Cell and B-Cell assays using ELISPOT, Luminex, multiparameter flow cytometry, and FACS technologies available in-house. Our objective is to identify potential correlates of protection and garner a deep understanding of dengue immunity and immune responses to candidate dengue vaccines. The Branch currently has several dengue vaccine candidates in clinical trials and will be utilizing dengue human infection models to evaluate vaccine candidates. The VDB is seeking applicants to advance immune investigations, in particular using single cell analysis and systems biology approaches.

 

References

Rothman et al: Analysis of cell-mediated immune responses in support of dengue vaccine development efforts. Vaccine 30: 7083-7090, 2015

Friberg et al: Cell-mediated immunity generated in response to a purified inactivated vaccine for dengue virus type-1. mSphere 5:e00671-19, 2020

Waickman et al: Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection. EBioMedicine 54:102733, 2020

Waickman et al: Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections. PLoS Pathogens 17(1):e1009240, 2021

 

key words

Dengue; Flow cytometry; Immunology; Systems biology; Viral diseases; Dengue; ICS; T-cells; Transcriptomics;

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens

Level:  Open to Postdoctoral and Senior applicants