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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Enteric Bacterial Pathogenesis, Vaccines, and Diagnosis

Location

Walter Reed Army Institute of Research, Infectious Diseases-Bacterial Diseases Branch

RO# Location
97.15.09.B3382 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Venkatesan, Malabi M. malabi.m.venkatesan.civ@mail.mil 301.319.9764

Description

Research focuses on the development of live, attenuated vaccines and subunit vaccines against the different serotypes of Shigella that cause bacillary dysentery. Candidate products are first evaluated for biological activity using in vitro tissue culture assays and later are evaluated for safety, immunogenicity, and efficacy in mice; guinea pig; and rhesus monkey models. Promising candidates are subject to clinical trials. For example, live, attenuated Shigella vaccines SC602, WRSS1, and WRSd1 have undergone Phase 1 trials in volunteers and proven to be immunogenic. Further attenuation of these candidates to reduce residual reactogenicity is in progress. Subunit compositions of Shigella, such as Invaplex, are currently undergoing clinical trials for safety and immunogenicity. Strategies for mucosal delivery and presentation of antigens utilizing live-attenuated Shigella carriers, or the adjuvant-like properties of Invaplex, are also under investigation. Methods used to develop vaccines, carriers, and adjuvants include recombinant DNA technology, protein purification techniques, immunology, cell biology, and animal models.

 

References

Ranallo RT, et al: Infection and Immunity 73: 258, 2005

Kaminski RW, et al: Infection and Immunity 74: 2856, 2006

 

Keywords:
Bacterial genetics; Bacterial immunology; Bacterial pathogenesis; Bacterial toxicology; Cell biology; Immunocytochemistry; Animal models; Vaccines;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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