Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Blast Induced Neurotrauma Branch
|Long, Joseph Benfer
Studies are conducted to characterize the etiology of the nervous system injuries associated with blast exposure and to identify efficacious countermeasures. Particular emphasis is placed on studies of (1) the biomechanical and pathophysiological mechanisms underlying blast-induced brain injury; (2) the combined effects of blast polytrauma and systemic hemorrhage, (3) the interplay of primary and tertiary blast and repeated blast exposures; and (4) blast-induced ocular, vestibular, and auditory impairments. Studies involve a state-of-the-art in vivo model of blast overpressure exposure and heparin-free hemorrhage. Techniques include real-time polymerase chain reaction, immuno-histochemistry and confocal microscopy, immunoblotting, Western blots, ELISAs, proteomic and genomic analyses, enzyme assays, comprehensive neurobehavioral assessments, electroretinography, auditory/vestibular functional assessments, telemetric EEG, and laser Doppler flowmetry. The goal of these studies is to increase our knowledge of blast-induced brain injury and to develop mitigation strategies and pharmacotherapeutics to limit injury propagation and promote recovery.
Wang Y, et al: Repeated blast exposures cause DNA fragmentation in mice. Journal of Neurotrauma 2013; in press. doi: 10.1089/neu.2013.3074. Epub 2013 Sept 27
Arun P, et al: Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase. Journal of Neurotrauma. 2013 Oct 1;30(19):1645-51. doi: 10.1089/neu.2012.2834. Epub 2013 Aug 9
Wang Y, et al: Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice. Journal of Neurotrauma. 2011 Oct;28(10):2171-83. doi: 10.1089/neu.2011.1990. Epub 2011 Oct 4
Blast; Brain injury; Sensory system injuries; Biological models; Acceleration; Polytrauma;