Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Blast Induced Neurotrauma Branch
|Yourick, Debra Lynn
Research is conducted in blast-induced neurotrauma to determine extent of injury through neuropathologic assessments, and therapeutic interventions through rodent models of repeated blast and blast plus weight-drop brain injury. Equipment is available for stereotaxic surgery and chronic radiotelemetered recording of EEG from freely moving rats, as well as behavioral and physiologic assessments, histochemical and biochemical preparation and analyses of brain tissue. Specific neuropathologic assessments such as fluorojade-B, silver-staining and stereology techniques are used. Seizures are evaluated using telemetric techniques and a published MATLAB algorithm for characterization and quantification of seizures and detected changes in EEG. See below for examples of application of our prior research experience in neuropharmacologic and neurophysiologic studies in organophosporus (nerve agent) to these new injury models. See also Research Opportunity 97.15.08.B6901.
Furtado M, et al: Journal of Neuroscience Methods 184(1): 176, 2009, Epub 2009 Jul 24
Furtado, M, et al: Epilepsia 51: 1503, 2010
Furtado M, Rossetti F, Yourick D.: Use of telemetric EEG in brain injury. in Ondrej Krejcar, Ph.D. (Org.) Modern Telemetry. Vienna: Intech open access publisher, 2011: 199. ISBN 978-953-307-415-3. Book chapter available at http://cdn.intechweb.org/pdfs/21097.pdf
Rossetti F, et al: Neurotoxicology 33(3): 500, 2012
de Araujo Furtado M, et al: Neurotoxicology 33: 1476, 2012
Rossetti F, de Araujo Furtado M, Yourick DL: Valproic acid and epilepsy: from basic research to clinical findings, in Valproic Acid: Pharmacology, Mechanisms of Action and Clinical Implications. Nova Science Publishers, Inc, 117: 2012.
Seizures; Neuropharmacology; Neurotoxicology; Intercellular communication; EEG telemetry; Neuroprotection; Behavior;