Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Military Psychiatry Branch
| name |
email |
phone |
|
| Marti Jett |
Marti.jett-tilton.civ@health.mil |
301-273-8789 |
The Integrated Systems Biology Research Center focuses on interdigitating global molecular characteristics with the clinical determinants. Therefore, our data include global metabolomics, epigenetics, miRNA, GWAS and targeted proteomics, exome studies, sequencing and other ancillary determinations. Our projects include a diverse array of Military-relevant health issues. Our work on post-traumatic stress disorder (PTSD) is the issue for which this solicitation is aimed. Our ongoing projects in PTSD include characterizing subgroups of PTSD, clinical trials to integrate molecular responses to therapeutic outcomes, pre and post deployment studies of Military personnel and development of a screening tool for early identification of PTSD (the latter is the most advanced project for which we currently are working with FDA).
To participate with this team, the applicant should have strong bioinformatics/computational skills to integrate molecular with clinical findings and have a sufficient background in the molecular laboratory techniques to be able to assist in technical guidance for laboratory staff. We require excellent writing skills and a good publication record.
References:
1. Gautam A, Kumar R, Chakraborty N, Muhie S, Hoke A, Hammamieh R, Jett M. Altered fecal microbiota composition in all male aggressor-exposed rodent model simulating features of post-traumatic stress disorder. . Journal of neuroscience research. 2018. Epub 2018/04/11. doi: 10.1002/jnr.24229. PubMed PMID: 29633335.
2. Synthia H. Mellon, Aarti Gautam, Rasha Hammamieh, Marti Jett, Owen M. Wolkowitz. Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder. Biological Psychiatry, Volume 83, Issue 10, 2018, Pages 866-875, ISSN 0006-3223.
3. Muhie, S., Gautam, A., Chakraborty, N., Hoke, A., Meyerhoff, J., Hammamieh, R. & Jett, M. Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder. Transl Psychiatry, 7, e1135.
Computational Biology; Bioinformatics; Molecular/clinical Data Integration; Global Multi-omics; Sequencing