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Opportunity at U.S. Army Medical Research & Materiel Command (AMRMC)

Neurotherapeutic Resuscitation for Military-relevant Polytrauma Associated with Traumatic Brain Injury (TBI)

Location

Walter Reed Army Institute of Research, Psychiatry & Neurosciences-Military Psychiatry Branch

RO# Location
97.15.06.B8360 Silver Spring, MD 20910

Advisers

Name E-mail Phone
Leung, Lai Yee laiyee.leung.ctr@mail.mil 301.319.7130

Description

In traumatic brain injury (TBI)-polytrauma patients, prevention of cerebral edema formation during pre-hospital resuscitation may improve survival rates and clinical outcomes. The primary objective of the proposed study is to examine the synergistic effect of anti-edema drugs and colloid resuscitation fluid during pre-hospital en-route when the TBI occurs in conjunction with hemorrhagic shock. More specifically, the efficacy of the neurotherapeutic resuscitation strategy on reducing brain edema, restoring tissue/cerebra perfusion, ameliorating neuroinflammation, as well as oxidative stress after the combined injury will be evaluated.

 

References

Leung LY, et al: Combined hypoxemic and hypotensive insults altered physiological responses and neurofunction in a severity-dependent manner following penetrating ballistic-like brain injury in rats. Journal of Trauma and Acute Care Surgery 79(4 Supplement 2): S130-8, 2015

Tortella FC, Leung LY: TBI and polytrauma in theatres of combat: the case for neurotrauma resuscitation? Shock 44(1): 17-26, 2015

Leung LY, et al: The acute effect of hemorrhagic shock on cerebral blood flow, brain tissue oxygen tension and spreading depolarization following penetrating ballistic-like brain injury. Journal of Neurotrauma 30(14): 1288-98, 2013

 

Keywords:
Traumatic brain injury; Polytrauma; Hemorrhagic shock; Resuscitation; Physiology; Cognitive; Penetrating ballistic-like brain injury; Motor; Mechanisms;

Eligibility

Citizenship:  Open to U.S. citizens, permanent residents and non-U.S. citizens
Level:  Open to Postdoctoral and Senior applicants
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