Opportunity at National Institute of Standards and Technology (NIST)
Molecular Biophysics and Protein Dynamics via Microfluidics and Ultrafast Spectroscopy Techniques
Physical Measurement Laboratory, Quantum Physics Division
Please note: This Agency only participates in the February and August reviews.
The laboratory employs techniques from biochemistry, chemical physics, and optics. We use femtosecond laser spectroscopy to quantify the spectra of motions by probing either the electronic transitions of a bound cofactor or ligand. Experiments on site-directed mutants or chemically modified proteins are used to determine the structural origins of the motions. We are also developing and employing microfluidics-based selection strategies on combinatorial libraries of red-fluorescent proteins to improve their photophysical properties and to generate new FRET-based sensors of metals and other analytes n vivo. Finally, we are extending the integration of spectroscopy with microfluidic flow-cytometry for development of new biophotonic functionality such as photoswitchable fluorophores.
Biophysics; Fluorescence; Spectroscopy; Microfluidics;
Open to U.S. citizens
Open to Postdoctoral applicants