|Goldfarb, Ron B.
|Greenlee, Lauren Fay
New metrology specialized for the detection and characterization of functionalized magnetic nanoparticles will enable ultrasensitive, highly specific, and rapid biochemical assays. Such assays would have immediate impact in the quantification of disease biomarkers, where functionalized magnetic nanoparticles would bind to target molecules, and the particles would be detected and quantified with new, high-gain, nanomagnetic devices. For water monitoring and purification, inert and reactive magnetic nanoparticles will absorb, collect, identify, and then degrade contaminants. Key problems are measurement of the strength and stability of particle-surface functionalization in liquid environments, and identification and quantitation of targeted molecules. The program will require research and innovation in new methods for the fabrication of magnetic nanoparticles with large magnetic moments and uniform sizes optimized for each application; stabilization of particles against oxidation; functionalization of particles to bind to target molecules with high sensitivity and specificity; physical and chemical characterization of nanoparticles; new methods to measure the strength of chemical adhesion of particle coatings and of their conjugation to target molecules; and development of new instruments for the detection and quantification of conjugated nanomagnetic particles with high signal-to-noise ratio, rapid response, and high throughput. Applicants primarily interested in nanoparticle fabrication, stabilization, and functionalization should contact Lauren Greenlee. Applicants primarily interested in nanoparticle detection and quantification should contact Ron Goldfarb.
Assays; Biomarkers; Contamination; Disease; Functionalized; Magnetic; Nanoparticles; Purification; Tagging; Water;