|Moreland, John Michael
Conventional magnetic resonance imaging (MRI) and spectroscopy (MRS) systems are limited in sensitivity and resolution because of the intrinsic noise associated with inductive detectors as well as difficulties generating field gradients sufficient for narrow sample slice discrimination. By using a microsystems approach, significant improvements in sensitivity and resolution can be made. Our goal is to explore, develop, and optimize MR imaging and spectroscopy for fundamental biological studies as well as potential biomedical applications with the sensitivity and resolution necessary for not only in-vitro single cell measurements but also for imaging cell organelles and membranes. Challenges include developing integrated microsystems with microfabricated dc and rf field sources, novel magnetic sensors, and novel field gradient coils interfaced to microfluidic environments. In addition, ideas related to developing new molecular imaging tags and contrast agents related to MR or new tags that utilize magnetic tomographic techniques are encouraged. Some interesting possibilities include, but are not limited to, scanning probe microscopy techniques (e.g., MRFM), optical imaging tags (e.g., nitrogen-vacancy centers in diamond nanoparticles), and magnetic particle imaging (MPI).
Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); MEMS; Microsystems; Cellular imaging; Cellular measurements; Microflidics; Magnetic particle imaging (MPI); Scanning probe microscope; Optical imaging tags;