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Opportunity at National Institute of Standards and Technology (NIST)

Structure-Function Determination of Membrane Proteins

Location

Physical Measurement Laboratory, Engineering Physics Division

RO# Location
50.68.31.B7578 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Kasianowicz, John J. john.kasianowicz@nist.gov 301.975.5853
Robertson, Joseph William joseph.robertson@nist.gov 301.975.2506

Description

Structures of membrane proteins have proven difficult to obtain using X-ray crystallography. To address this issue, we are using neutron reflectometry, small-angle neutron scattering, surface plasmon resonance, and electrophysiology to determine the structure, function, and mechanism of assembly of membrane proteins. Current molecules of interest include, but are not limited to, bacterial toxins that are biowarfare agents (e.g., anthrax, clostridium).

 

References

McGillivray DJ, et al: Biophysical Journal 96: 1547, 2009

McGillivray DJ, et al: Biointerphases 2: 21, 2007

 

Keywords:
Membrane protein; Structure; Function; Neutron reflectometry; Electrochemistry; Surface plasmon resonance;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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