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Opportunity at National Institute of Standards and Technology (NIST)

Absolute Quantitation in Molecular Imaging


Physical Measurement Laboratory, Radiation Physics Division

RO# Location
50.68.21.B8017 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.


Name E-mail Phone
Bergeron, Denis Eugene 301.975.2282


Increasing reliance on molecular imaging as a biomarker for disease progression and response to therapy dictates a need for absolute measurement standards for true quantitation. Molecular imaging techniques based on photon counting (i.e., PET and SPECT) are inherently amenable to true quantitation, but many physical and biological hurdles to reliable and consistent calibration exist. The Nuclear Medicine Project within the Radioactivity Group at NIST addresses some of these hurdles in an effort to provide the foundations for absolute quantitation in imaging.

NIST houses a clinical PET/CT scanner that is dedicated purely to physics experiments; with no patients being scanned, researchers do not have to compete with clinicians for instrument time. Current and future projects include the development of long-lived calibration surrogates for short-lived radiopharmaceuticals, quantitative measurements of partial volume effects and the efficacy of various correction techniques, the measurement impact of variations in the positronium branching ratio and its dependence on chemical environment, and quantitative imaging with exotic positron emitters.

The Associate will gain extensive experience in the acquisition and analysis of PET/CT data and in basic metrological techniques.


PET/CT; Molecular imaging; Nuclear medicine; Quantitation; Multi-center trial; Radionuclide metrology; Radiopharmaceutical;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$72,028.00 $3,000.00
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