Nuclear magnetic resonance (NMR) spectroscopy has several important advantages for quantitative measurements of amount of substance: authentic material is not required for calibration, sample conditions are mild and nondestructive, a wide molecular mass range is accessible, and low uncertainties are readily achieved. Despite these advantages, the use of quantitative NMR (qNMR) has been largely limited to one-dimensional 1H NMR on liquid samples. Part of the reason for such narrow use of qNMR is that high-quality standards are lacking. It is worth noting that, even for liquid-phase 1H NMR, commercial qNMR standards have only appeared in the last few years. We seek proposals related to the development of high-accuracy methods or standard reference materials for the analysis of gas-phase mixtures. Mixtures of interest include natural gas, refrigerant mixtures (e.g., R-410a), and vapor samples that are important to forensic science (e.g., fuel vapors associated with arson). We are also interested in using NMR to study gas separations and vapor-liquid equilibria for commercially important gas-phase mixtures. Proposals are welcome to consider a variety of nuclei (such as 1H, 19F, 13C, and 31P) or the use of multidimensional spectra. A 600 MHz NMR with a variety of probes will be at the disposal of the researcher, along with a variety of other analytical methods.
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Nuclear magnetic resonance spectroscopy; NMR; Quantitative NMR; qNMR; Standard reference materials; Method development; 1D and 2D NMR; Multidimensional NMR; Gas-phase mixtures;