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Opportunity at National Institute of Standards and Technology (NIST)

Novel Imaging Strategies for Nanomedicine

Location

Material Measurement Laboratory, Applied Chemicals and Materials Division

RO# Location
50.64.72.B8096 Boulder, CO

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Jeerage, Kavita M jeerage@boulder.nist.gov 303.497.4968

Description

Next generation nanomedicine will consist of nanoparticle-based therapies that target specific cell populations. Nanoparticle-based therapies have the potential to reduce the dangerous side effects of chemotherapy drugs (by targeted destruction of cancer cells) and combat diseases such as cystic fibrosis (by targeted delivery of genes to lung cells). Investigating how engineered particles interact with, are internalized, and/or are trafficked through, biological cells is critical to the success of these ventures. To detect nanoparticles inside statistically relevant populations of individual cells, we are developing an approach that builds on focused ion beam tomography, which can mill specific cells within complex cultures to reveal internalized metal nanoparticles. We are particularly interested in strategies that create cellular contrast in the scanning electron microscope, but maintain nanoparticle contrast. Proposals could also be application focused; one example is designing particles that accumulate in different cellular compartments. A variety of optical and electron microscopes are available for this research.

 

Keywords:
Cells; FIB; Imaging; Nanomedicine; Nanoparticles; SEM;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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