This opportunity focuses on the development and implementation of liquid chromatography mass spectrometry methods for the quantitation of hormones in biological matrices. Hormones are essential for major developmental and reproductive processes. Because hormones are highly similar in structure and found at nanomolar concentrations, identification and quantitation are difficult. In this position, fellows would be tasked with developing advanced methods for the measurement of steroid, thyroid, or peptide hormones, and applying them to biological sample sets. Projects could include analysis of the effects of contaminants or other exposures on endocrinology, basic endocrinology, or untargeted compound discovery.
Boggs ASP, Schock TB, Schwacke LH, Galligan TM, Morey JS, McFee WE, Kucklick JR: Rapid and reliable steroid hormone profiling in Tursiops truncatus blubber using liquid chromatography tandem mass spectrometry (LC-MS/MS). Analytical and Bioanalytical Chemistry (Accepted June 2017) 2017
Boggs ASP, Bowden JA, Galligan TM, Guillette LJ Jr, Kucklick JR: Development of a Multi-class Steroid Hormone Screening Method using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Analytical and Bioanalytical Chemistry 408: 4179-4190, 2016
Boggs ASP, Hamlin HJ, Nifong JC, Kassim BL, Lowers RH, Galligan TM, Long SE, Guillette LJ Jr: Urinary iodine and stable isotope analysis to examine habitat influences on thyroid hormones among coastal dwelling American alligators. General and Comparative Endocrinology 226: 5-13, 2016
Steroid; Thyroid; Biology; Endocrinology; Endocrine Disruption; LC-MS/MS; High Resolution MS; Untargeted omics;