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Opportunity at National Institute of Standards and Technology (NIST)

Lipidomics as an Environmental Health Assessment Strategy

Location

Material Measurement Laboratory, Chemical Sciences Division

RO# Location
50.64.63.B8124 Charleston, SC

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Bowden, John A john.bowden@nist.gov 843-725-4820

Description

We are seeking postdoctoral researchers to help in developing new analytical approaches for both studying and addressing measurement challenges associated with lipids. Placement would be at the Hollings Marine Laboratory in Charleston, SC, which is a collaborative facility among NIST, the National Oceanic and Atmospheric Administration, the College of Charleston, the Medical University of South Carolina, and the South Carolina Department of Natural Resources. The focus of the effort would be on developing novel analytical strategies in the emerging field of environmental forensics.

Parallel to humans, several wildlife species have exhibited an increase in the occurrence of disease states, including cancers, altered metabolism, decreased fertility, inflammation, and impaired development. Thus, a current emphasis in our group has been focused on expanding beyond the traditional detection of anthropogenic contaminants in wildlife to developing innovative methods capable of providing information on the fundamental question, “what are the health-related consequences of contaminant exposure to an animal and its progeny?” We are currently pursuing and adapting omics-based approaches commonly employed in human disease state detection, such as lipidomics and metabolomics. While the traditional platform for lipidomics has generally been limited to clinical studies, the application of lipidomics for assessing environmental health presents a promising new direction. To adapt lipidomics to environmental studies, efforts have been placed to develop and tailor analytical strategies (chromatography, mass spectrometry, data informatics) for the detection of novel disease state biomarkers and to apply these developed strategies to environmental diseases/conditions to increase our understanding of the disease/biomarker relationship and ultimately disease etiology.

 

Keywords:
Mass spectrometry; Lipidomics; Environmental forensics; Metabolomics; Chemometrics; Environmental chemistry; Human health; Liquid chromatography; Chemistry;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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