Developing bioanalytical foundations for multi-omics analysis in non-model marine organisms
Recent advances in genomic sequencing technologies have created a tremendous flux of new high-quality genomes for a multitude of non-model species. With each new genome many downstream applications become possible including transcriptomic and proteomic analysis. This project aims to develop and disseminate technological resources for non-model organisms. Specifically this includes demonstrating the capabilities and utility of transcriptomic and proteomic techniques in diverse species, making data available and creating programmatic tools for comparing between species. Additionally, this project will employ emerging proteomics techniques (such as data-independent acquisition) and will be working alongside software and algorithm developers to ensure that these platforms can be used beyond human data sets. Due to the multidisciplinary nature of this project, we are seeking applicants with experience in transcriptomics, proteomics and bioinformatics.
Carolina Möller, Sanaz Dovell, Christian Melaun, Frank Marí Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds. Peptides. 2018 Sep;107:75-82. doi: 10.1016/j.peptides.2018.06.002. Epub 2018 Jul 21. PMID: 30040981.
S.W.A. Himaya, Frank Marí, Richard Lewis, Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals, Nature Scientific Reports, 2018 8:330. DOI:10.1038/s41598-017-17422-x.
Aldo Franco, Sanaz Dell, Carolina Moller, Meghan Grandal, Evan Clark, Frank Marí, Structural Plasticity of Mini-M Conotoxins: Expression of all mini-M subtypes by Conus regius. FEBS J. 2017 Dec 28. doi: 10.1111/febs.14372. [Epub ahead of print] PMID:29283511.