Research focuses on the development and application of multi-detector, multi-dimensional macromolecular separation science techniques. Topics include (1) designing macromolecular two-dimensional liquid chromatography (2D-LC) separations to characterize the physicochemical phase space inhabited by complex polymers, blends, and novel materials; (2) physicochemical characterization of nanoparticles by SEC, HDC, AF4, H5F separations coupled to e.g., MALS, QELS, ICP-MS, etc.; (3) non-empirical, first-principles-based development of novel "interactive" macromolecular LC methods; (4) quantitative determination of structural influences on solution flexibility of small sugars (mono-, di-, and oligosaccharides); (5) physicochemical characterization of polyelectrolytes; (6) determining structural and related influences on transient elongational flow-induced polymer degradation; and (7) thermodynamics of dilute polymer solutions. Reseach will emphasize applications to macromolecular, analytical, carbohydrate, and nanoparticle disciplines.
Rowland SM, Striegel AM: The characterization of copolymers and blends by quintuple-detector size-exclusion chromatography. Analytical Chemistry 84: 4812-4820, 2012
Brewer AK, Striegel AM: Characterizing string-of-pearls collodial silica by multidetector hydrodynamic chromatography and comparison to multidetector size-exclusion chromatography, off-line multiangle static light scattering, and transmission electron microscopy. Analytical Chemistry 83: 3068-3075, 2011
Separation science; Multiple detection; Multi-dimensional; Macromolecules; Polymers, Carbohydrates; Nanoparticles; Polysaccharides; Liquid chromatography;