Oligonucleotide Analysis by Mass Spectrometry
Material Measurement Laboratory, Biomolecular Measurement Division
NIST only participates in the February and August reviews.
Robust analytical characterization of oligonucleotides is essential to the production of safe and consistent RNA-based products, and is a necessary part of a biomanufacturing design. This opportunity focuses on developing advanced techniques in mass spectrometry for detecting, identifying, and quantifying oligonucleotides and impurities in various forms, with a focus on healthcare, therapeutics, and vaccines. Available instrumentation includes high resolution mass spectrometry (QToF, QExactive, Orbitrap) and quantitative mass spectrometry (QQQ-MS) with liquid chromatography. We encourage applicants who want to join a growing field and make an impact.