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Opportunity at National Institute of Standards and Technology (NIST)

Oligonucleotide Analysis by Mass Spectrometry

Location

Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.C0658 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Lowenthal, Mark Scott mark.lowenthal@nist.gov 301.975.8993

Description

Robust analytical characterization of oligonucleotides is essential to the production of safe and consistent RNA-based products, and is a necessary part of a biomanufacturing design.  This opportunity focuses on developing advanced techniques in mass spectrometry for detecting, identifying, and quantifying oligonucleotides and impurities in various forms, with a focus on healthcare, therapeutics, and vaccines.  Available instrumentation includes high resolution mass spectrometry (QToF, QExactive, Orbitrap) and quantitative mass spectrometry (QQQ-MS) with liquid chromatography.  We encourage applicants who want to join a growing field and make an impact.

Keywords:
oligonucleotides; RNA; mass spectrometry; LC-MS/MS; therapeutics; vaccines; CRISPR-Cas; mRNA

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants

Stipend

Base Stipend Travel Allotment Supplementation
$72,750.00 $3,000.00
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