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Opportunity at National Institute of Standards and Technology (NIST)

Structure-function Studies of Antimicrobial Peptides in Lipid Membranes

Location

Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B8557 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Marino, John P. john.marino@nist.gov 240.314.6160

Description

The innate immune response, which is the first line of defense against an infection or injury, is mediated by a variety of immune effector molecules that regulate molecular recognition at the plasma membrane. During the first phase of the response, pathogens are targeted by constitutively produced proteins, e.g. host-defense peptides (HDP),  the plasma membrane being a primary target. Understanding the mechanism of HDPs  at the molecular level is critical for designing more potent variants.   Our research group is developing biophysical techniques to interrogate peptide-membrane interactions at the molecular level. We are particularly focused on employing Neutron Reflectivity and Diffraction methods for structural analysis as well as Surface Plasmon Resonance (SPR) and Electrochemical Impedance (EI) spectroscopy for functional and kinetic studies. The interdisciplinary research is carried out at the NIST Center for Neutron Research (NCNR) and at the Institute for Bioscience and Biotechnology Research which have state-of-the art capabilities for cold neutron measurements, protein expression and stable-isotope labeling of biomolecules.

Keywords:
structure, function, antimicrobial peptides, lipids, membranes, neutron reflectivity, neutron diffraction, SPR, EIS

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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