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Opportunity at National Institute of Standards and Technology (NIST)

RNA Structural Analysis Using Single-Molecule Fluorescence Measurements

Location

Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B8507 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Marino, John P. john.marino@nist.gov 240.314.6160

Description

Ribonucleic acid (RNA) can fold into a variety of complex structures and as a result, participate in a wide range of biological processes. RNA has a tendency to adopt multiple conformations, making it difficult to define unique structures and detect transient or low occupancy states. Furthermore, the ability to gain sequence information has greatly outpaced our ability to gain any information about RNA structure and dynamics. Therefore, the aim of this research is to develop fluorescence-based methods for screening RNA molecules for structure at the single-molecule level and in a high-throughput manner. Ultimately, advancing RNA structural metrology will further biomedical research, drug discovery, and emerging synthetic biology efforts to engineer biological systems.

 

Keywords:
RNA structure; Biochemistry; Fluorescence; Single-molecule; High-throughput;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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