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Complex DNA Mixture Interpretation


Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B8438 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.


Name E-mail Phone
Coble, Michael D 301.975.4330


Forensic DNA profiling of short tandem repeat (STR) markers using PCR has become an important tool for human identification. When the stain from the crime scene derives from a single individual, a match to a reference profile can produce an extremely rare random match probability. When the evidence contains DNA from multiple contributors, DNA mixtures can become very complicated to interpret, especially if the DNA from one or more of the contributors is degraded, or if the contributors share multiple alleles. The Applied Genetics Group at NIST is currently exploring and testing both commercially available and open source software tools for complex DNA mixture interpretation. Other projects include the creation of educational and training modules via publications, workshops, and webcasts to understand new approaches to mixture interpretation along with additional interlaboratory exercises to help laboratories identify areas for improvement in mixture protocols.



Bieber FR, et al: Evaluation of Forensic DNA Mixture Evidence: Guidelines for Evaluation, Interpretation, and Statistical Calculations using the Combined Probability of Inclusion. BMC Genetics 17(1): 125, 2016

Coble MD, et al: DNA Commission of the International Society for Forensic Genetics: Recommendations on the validation of software programs performing biostatistical calculations for forensic genetics applications. FSI Genetics 25: 39-44, 2016

Coble MD, et al: Uncertainty in the number of contributors in the proposed new CODIS set. FSI Genetics 19: 207-211, 2015


Forensic genetics; DNA mixtures; Short tandem repeat; Probabilistic genotyping; DNA mixture software; DNA profiling;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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