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Opportunity at National Institute of Standards and Technology (NIST)

Engineered Nanomaterial Induced Genotoxicity


Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B7403 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.


Name E-mail Phone
Dizdar, Murat Miral 301.975.2581
Nelson, Bryant C. 301.975.2517


Engineered nanomaterials (ENMs) often exhibit exceptional physical, chemical, and electrical properties. These unique properties drive the expanded use of ENMs in industrial, medical, and consumer-product markets, but raise serious questions regarding their potential for unforeseen environmental health and human safety risks. This motivates extensive research on the “toxic potential” of ENMs with a recognized need to acquire a quantitative and mechanistic understanding of ENM-biomolecule interactions. In particular, there exists an urgent need to develop and apply advanced measurement strategies towards understanding ENM-biomolecule interactions that mediate cellular toxicity and/or oxidative stress. Our laboratory focuses on the molecule of life: DNA. We have immediate openings for Associates who have a specific interest in conducting leading-edge research in ENM-induced genotoxicity with a focus on new and emerging ENMs that have the capacity to mediate oxidative damage to DNA. Potential Associates should be interested in conducting independent research that (1) develops a thorough quantitative and mechanistic understanding of ENM-induced oxidative damage to DNA using relevant in vitro and in vivo experimental models, (2) delineates the biological processes involved in ENM-induced upregulation/downregulation and/or systemic modification of characteristic DNA repair enzymes, (3) involves the development and application of novel hyphenated mass spectrometry methodology (GC-MS/MS and LC-MS/MS) for the quantitative determination of ENM-induced DNA base and/or nucleoside modifications, or (4) involves the development and application of computational modeling/simulations for understanding in vivo interactions of ENMs with cellular DNA or DNA repair enzymes that mediate cellular genotoxicity.

DNA damage; Engineered nanomaterial; Genotoxicity; Mass spectrometry; Nanoparticles; Nanotoxicity; Oxidative stress;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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