Engineered nanomaterials (ENMs) often exhibit exceptional physical, chemical, and electrical properties. These unique properties drive the expanded use of ENMs in industrial, medical, and consumer-product markets, but raise serious questions regarding their potential for unforeseen environmental health and human safety risks. This motivates extensive research on the “toxic potential” of ENMs with a recognized need to acquire a quantitative and mechanistic understanding of ENM-biomolecule interactions. In particular, there exists an urgent need to develop and apply advanced measurement strategies towards understanding ENM-biomolecule interactions that mediate cellular toxicity and/or oxidative stress. Our laboratory focuses on the molecule of life: DNA. We have immediate openings for Associates who have a specific interest in conducting leading-edge research in ENM-induced genotoxicity with a focus on new and emerging ENMs that have the capacity to mediate oxidative damage to DNA. Potential Associates should be interested in conducting independent research that (1) develops a thorough quantitative and mechanistic understanding of ENM-induced oxidative damage to DNA using relevant in vitro and in vivo experimental models, (2) delineates the biological processes involved in ENM-induced upregulation/downregulation and/or systemic modification of characteristic DNA repair enzymes, (3) involves the development and application of novel hyphenated mass spectrometry methodology (GC-MS/MS and LC-MS/MS) for the quantitative determination of ENM-induced DNA base and/or nucleoside modifications, or (4) involves the development and application of computational modeling/simulations for understanding in vivo interactions of ENMs with cellular DNA or DNA repair enzymes that mediate cellular genotoxicity.
DNA damage; Engineered nanomaterial; Genotoxicity; Mass spectrometry; Nanoparticles; Nanotoxicity; Oxidative stress;