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Opportunity at National Institute of Standards and Technology (NIST)

RNA Structure and Function of Marine Viruses Using High Field Nuclear Magnetic Resonance

Location

Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B7204 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Marino, John P. john.marino@nist.gov 240.314.6160

Description

Nuclear magnetic resonance has become a powerful tool for the elucidation of protein and nucleic acid structure and dynamics. The research focuses on the development and application of high-resolution NMR and other biophysical methodology for the analysis of RNA structure in marine systems that have applicability to human health. Current projects include the study of the 5’ and 3’ untranslated regions of the infectious salmon anemia virus (ISAV), a negative-strand RNA virus that infects salmon. This research represents the first in-depth structural study of the “panhandle” RNA motif in ISAV and could form the structural basis for future rational development of therapeutic treatments for ISAV. A secondary focus of our work entails the development of chemical and spin probes to further elucidate understanding of these systems.

 

Keywords:
Chemical probes; Marine viruses; Nuclear magnetic resonance; RNA; Structure and function;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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