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Opportunity at National Institute of Standards and Technology (NIST)

Metrology Tools for Biomanufacturing

Location

Material Measurement Laboratory, Biomolecular Measurement Division

RO# Location
50.64.51.B6742 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Ripple, Dean dripple@nist.gov 301.975.4801

Description

This research involves the development of measurement methods, sensors, or standards for characterizing key attributes of manufactured biological products, primarily therapeutic proteins that impact their efficacy and safety. Of particular interest is the measurement of protein aggregates and protein particulates. These efforts range from studying fundamental aspects of protein aggregation to the development of potential reference materials for improved measurements of protein aggregates and particulates. Methods used in our studies include microflow imaging, light obscuration, coulter counting, size exclusion chromatography, light scattering, atomic force microscopy, and electrospray ionization-differential mobility analysis.

 

Keywords:
Biomanufacture; Bioprocessing; Glycoprotein; Process analytical technology; Protein aggregation; Vaccine; Virus;

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants
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