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Opportunity at National Institute of Standards and Technology (NIST)

Advanced Methods for Measuring Microbial Viability

Location

Material Measurement Laboratory, Biosystems and Biomaterials Division

RO# Location
50.64.41.C0605 Gaithersburg, MD

Please note: This Agency only participates in the February and August reviews.

Advisers

Name E-mail Phone
Dunkers, Joy P. joy.dunkers@nist.gov 301.975.6841

Description

The success of any antibiotic or antimicrobial approach rests in the developer’s ability to demonstrate it can effectively kill bacteria or severely retard their growth. In addition, the success of a microbial therapeutic or probiotic product relies on knowing viable count. Correctly determining bacterial viability, in other words whether an individual cell is alive or dead, is a critical and challenging measurement. Our goal is to develop advanced methods for rapidly, accurately and quantitatively measuring the viability of mixed microbial populations. This project will focus on the development of systematic, reliable methods for measuring viability of individual cells in a population. Understanding the effect of sublethal dosing chemical, antibiotic or UV antimicrobial treatments on viability and pathogenicity is critical insight that will help drive the success of real-world antimicrobial technologies. General approaches may include advanced imaging modalities, high-throughput technologies, standards and reference material development, and validation against existing compendial methods. The development of techniques to quantify viability will provide the means to reliably screen mixed microbial populations in vitro. 

Keywords:
microbe; bacteria; viability; antimicrobial; community; population; pathogen

Eligibility

Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants

Stipend

Base Stipend Travel Allotment Supplementation
$72,750.00 $3,000.00
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